Home Sports How exercise changes the brain: scientific evidence on why physical activity is the most powerful medicine for the psyche

How exercise changes the brain: scientific evidence on why physical activity is the most powerful medicine for the psyche

by Cameron Shepherd

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In 2024, a study from the University of California showed that 30 minutes of walking a day increases the volume of the hippocampus—the region of the brain responsible for memory and emotion—by 2% over a year. This is equivalent to “rejuvenating” the brain by 1–2 years. Exercise doesn’t just improve mood—it restructures neural networks, combating depression at the biological level.

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The mechanism is simple: physical activity stimulates the production of BDNF, a protein similar to fertilizer for neurons. It promotes the growth of new cells, strengthens the connections between them, and protects against degeneration. People who exercise regularly have 30–50% higher BDNF levels compared to sedentary individuals. This explains why exercise is more effective than antidepressants in 60% of patients with mild to moderate depression.

Interestingly, the type of activity doesn’t matter—it’s the consistency that matters. Even dancing, yoga, or gardening increase BDNF. The key is to exercise enough to cause slight shortness of breath and sweating. This is the signal to the brain: “We’re moving, which means we’re alive.”

Exercise reduces cortisol levels—the stress hormone—by 25–40% after just four weeks of daily exercise. At the same time, serotonin, dopamine, and endorphin levels increase. These aren’t metaphorical “happiness chemicals”—they’re real molecules that alter the perception of pain, anxiety, and life itself.

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